Scancell Holdings (SCLP)

Sector:

Pharma and Biotech

Index:

FTSE AIM All-Share

13.75p
   
  • Change Today:
    -0.38p
  • 52 Week High: 22.75
  • 52 Week Low: 10.63
  • Currency: UK Pounds
  • Shares Issued: 791.92m
  • Volume: 515,080
  • Market Cap: £108.89m

Scancell treats first patient in melanoma tumour trial

By Josh White

Date: Friday 19 Nov 2021

LONDON (ShareCast) - (Sharecast News) - Cancer and infectious disease immunotherapy developer Scancell announced on Friday that the enrolment and treatment of the first patient had taken place in its multicentre phase 2 clinical trial of its 'SCIB1' tumour treatment at the Churchill Hospital in Oxford.
The AIM-traded firm said the phase 2 study was designed to assess whether the addition of SCIB1 to pembrolizumab, known by the trade name Keytruda, would result in an improvement in the tumour response rate, progression-free survival and overall survival in patients with advanced melanoma.

As a result of the Covid-19 pandemic, screening and recruitment into the study was paused due to the prioritisation of coronavirus patients in UK hospitals.

Patient screening had now been re-initiated across the UK, however, with Poulam Patel, professor of clinical oncology at the University of Nottingham, acting as chief investigator.

The company said the Nottingham site, along with the Oxford centre, Velindre Hospital and Mount Vernon Hospital, were actively screening subjects, with additional centres due to join them in the coming months.

Scancell said SCIB1 is the lead product from its 'ImmunoBody' immunotherapy platform, which uses the body's immune system to identify, attack and destroy tumours.

That, it said, was achieved by delivering a DNA plasmid using Ichor's 'TriGrid 2.0' electroporation delivery device, to enhance the uptake and presentation of cancer antigens to harness high-avidity T-cell responses.

In a phase 1 and 2 clinical trial, survival following SCIB1 monotherapy was superior to historical survival rates, with 14 of 16 resected patients surviving for more than five years.

Although pembrolizumab is an approved therapy for advanced melanoma, response to treatment was limited to only around 30% of patients.

The company said the phase 2 study was designed to assess whether the addition of SCIB1 treatment to pembrolizumab would result in an improvement in patient outcomes.

"We are delighted to have started our SCIB1 phase 2 trial in the UK as we believe that SCIB1 administration in combination with an immune checkpoint inhibitor such as pembrolizumab has the potential to offer greater efficacy than when either agent is used alone," said chief executive officer Lindy Durrant.

At 1303 GMT, shares in Scancell Holdings were up 1.1% at 20.22p.

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SCLP Market Data

Currency UK Pounds
Share Price 13.75p
Change Today -0.38p
% Change -2.65 %
52 Week High 22.75
52 Week Low 10.63
Volume 515,080
Shares Issued 791.92m
Market Cap £108.89m

SCLP Star Ratings

Compare performance with the sector and the market.
more star ratings
Key: vs Market vs Sector
Value
47.48% below the market average47.48% below the market average47.48% below the market average47.48% below the market average47.48% below the market average
45.45% below the sector average45.45% below the sector average45.45% below the sector average45.45% below the sector average45.45% below the sector average
Price Trend
14.14% below the market average14.14% below the market average14.14% below the market average14.14% below the market average14.14% below the market average
33.33% above the sector average33.33% above the sector average33.33% above the sector average33.33% above the sector average33.33% above the sector average
Income Not Available
Growth Not Available

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SCLP Dividends

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Trades for 24-Jun-2022

Time Volume / Share Price
16:04 24,379 @ 13.63p
16:04 24,379 @ 13.50p
15:36 36,009 @ 13.85p
14:16 14,529 @ 13.70p
12:55 2,142 @ 14.00p

SCLP Key Personnel

CEO Lindy Durrant

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